Since his range is long but his cooldown is slow, sharpshooting skills, such as aiming ahead of the enemy's direction of travel, are needed to utilize Byron well. However, with his fast projectile speed, aiming with Byron is easier than with other long-ranged Brawlers such as Brock or Bea. Unless there are no enemies near faraway allies, prioritize allies closest to you.
To take advantage of Byron’s range is to chip away at enemies with his stacking tick damage while also dodging their fire, and once they’re low on health, you can use your Super to finish them off. This strategy will allow Byron to better secure defeats.
Byron's long range, high tick damage, and healing abilities truly shine in Team Events because he can consistently heal his teammates and himself with his attack, Super, and Shot In the Arm Gadget alike while they work towards the event objective with the healing giving more ease. Doing so will almost guarantee a positive outcome as the healing decreases enemy damage while assisting allies. In addition, he’s also effective at preventing enemies from healing, making it easier to cripple the enemy team.
Byron is outstanding at supporting close-ranged Brawlers like Edgar as Byron's allies can play aggressively, and if applicable, ambush enemies with their Supers or by bush-camping while Byron can consistently and quickly heal them from a safe distance.
When your attack is auto-aimed, it prioritizes the closest target to you. When fighting alongside a teammate, manually aim to hit the enemy and keep your distance, and even if you have his Injection Star Power, which allows you to chain attacks to hit both allies and enemies, you should still maintain a safe distance away from teammates that is far enough to damage enemies but close enough to heal allies without the disadvantages of long-range aiming.
Byron functions well with 8-Bit as 8-Bit's damage booster boosts Byron's healing abilities and Byron can use this to heal 8-Bit who already has high health. This combination is very effective in Duo Showdown. The combo is also extremely devastating in Siege; if the team dives into the enemy IKE turret's range to attack it, the boosted healing from Byron will momentarily protect 8-Bit while he uses his high damage and his Extra Credits Gadget to take out a major portion, if not all, of the IKE's health. Conversely, these two Brawlers in an enemy team should be monitored closely and be approached with caution.
Byron is niche in Super City Rampage as he can heal allies while they aggressively attack the Boss. An excellent team composition in this event is himself with his Injection Star Power, Pam, and one who can stall the Boss such as Edgar/Nita. For Edgar, he should use his Fisticuffs Star Power; for Nita, she should use her Bear With Me Star Power. If Edgar is the stalling Brawler, he should continuously stall the Boss with his high burst damage and the healing provided from his attack, Pam and Byron, and these should make him able to overcome the Boss's damage. For Nita, she should charge up her Super and spawn Bruce near the Boss opposite of Nita, and Nita and Bruce should take turns attacking and healing each other, and with Pam's and Byron's healing, Nita and Bruce can withstand more damage.
Byron's Booster Shots Gadget is best used to poison multiple enemies, heal multiple allies, or a combination of the two. It can also be used to heal or poison a single target for more damage/health than a regular shot, and can act as a form of close-range defense in combination with his Super. The gadget is good for killing low health enemies up close, although sometimes byron will die too when he uses it up close.
16/12/20 Byron was added to the game.
13/01/21 Byron's Injection Star Power was added.
08/02/21 Byron's health was decreased to 2400 (from 2500). His main attack damage/heal was decreased to 380 (from 400) per shot.
07/04/21 Byron's main attack damage/heal was decreased to 340 (from 380) per shot. The number of hits necessary to charge Byron's Super was increased to 10 hits (from 9).
16/06/21 Byron's Malaise Star Power enemy healing reduction effect was increased to 75% (from 50%).
17/06/21 The number of hits necessary to charge Byron's Super was decreased to 9 hits (from 10).
25/08/21 Byron's Shot In The Arm Gadget can now be used when Byron is at full health.
30/08/21 The Wizard Byron skin was added. It was featured as a Power League exclusive skin for Brawl Pass Season 8.
28/09/21 Fixed an issue where Wizard Byron's animations were glitching when using jump pads.
01/03/22 Byron's Booster Shots Gadget was added.
27/04/22 The number of hits necessary to charge Byron's Super was increased to 12 hits (from 9). Wizard Byron's losing animation was reworked. Fixed an issue with Byron's voice lines.
08/06/22 The Overlord Byron skin was added. It was featured as a Worst Bunch skin.
29/06/22 Byron's reload time was increased to 1.6 seconds (from 1.3). Byron and all of his skins' main attack visual effects were slightly reworked.
31/08/22 Byron's True Silver and True Gold skins were added.
28/02/23 Byron's reload time was decreased to 1.45 seconds (from 1.6).
25/04/23 Wizard Byron now costs 149 Gems (from 25000 Star Points).
05/09/23 The number of hits necessary to charge Byron's Super was decreased to 9 hits (from 12). All Brawlers' health and damage were increased from 5% to 10% with each Power Level.